Fundamentals of Molecular Biology

1.

Subject title

Fundamentals of Molecular Biology

Основи на молекуларна биологија

2.

Code

BI-Z-01

3.

Study program

Bioinformatics, Bioinformatics, IT management, Cloud Computing, Data science in computer science and engineering, Security, Cryptography and Coding, Еducation with ICT, Eco-informatics, Inteligent Systems, Internet Technologies and cyber security, Computer Science, Statistics and Data Analytics, Software for embedded systems, Software Engineering, Cloud Computing, IT management, Security, Cryptography and Coding, Statistics and Data Analytics, Software Engineering,

4.

Organizer of the study program (unit, institute, department, division)

Faculty of Information Sciences and Computer Engineering

5.

Study cycle (first, second, third)

Втор циклус

6.

Academic year / semester

5 / Зимски

7. Number of ECTS credits

6.0

8.

Instructor

виз. проф. д-р Сашо Панов

9.

Prerequisites for enrollment

10.

Subject goals and competencies:

Students should acquire basic and expanded knowledge of molecular biology, structure and function of biomacolecules (DNA, RNA and protein) and basic processes: replication, transcription and translation.

11.

Subject content:

Introduction - basic concepts and historical review. Definition of molecular biology. A short historical review. Central dogma of molecular biology. DNA molecules as carriers of genetic information; EMERI`s experiment; The experiment of Hirschi and Chase. Basic characteristics of hereditary material; DNA structure; Watson-Krikov model for the structure of the DNA molecule; structural organization of the DNA molecule in chromosomes; superspiralized structure of circular DNA molecules; Nucleosomal organization of DNA at Eckaryot. DNA replication; Mezelson and Stal`s experiment; DNA polymerases; initiating replication; replication fork; elongation; Replisome - a molecular machine for DNA replication; specifics of DNA replication in eukaryotes; replication problem with telomeric ends; Terminating DNA replication. Transcription - Synthesis of RNA after DNA template. Structure and function of RNA molecules. Transcription of the prokaryotes; Incification of transcription, transcriptional and transcription termination of E. coli. Transcription in eukaryotes. Post -transcripial modifications; Processing 5 and 3 ends of the primary transcript of protein coding genes. RNA SPOSING - Recreation of the primary RNA transcript; Alternative clamping. Translation - protein synthesis. Genetic code. RNA transport; Connecting the amino acids to TRNA. Ribosomes like transsuitant machinery. Translation process; Initiation, elongation and transitional termination. Protein - nomenclature, size of protein molecules. Protein structure levels - primary, secondary, tertiary and quaternary structure. Structural classification of protein. Examples of globular, fibrillary and membrane protein. Transitional regulation; Post -transverse events. Post -radiation modification of protein.

12.

Learning methods:

Предавања поддржани со презентации преку слајдови, интерактивни предавања, вежби (користење на опрема и софтверски пакети), тимска работа, пример случаи, поканети гости предавачи, самостојна изработка и одбрана на проектна задача и семинарска работа, учење во електронско опкружување (форуми, консултации).

13.

Total available time fund

6.0 ECTS x 30 hours = 180 hours

14.

Time distribution

60 + 0 + 45 + 45 + 30 = 180 hours

15.

Forms of teaching activities

15.1.

Lectures - theoretical teaching

60 hours

15.2.

Exercises (laboratory, classroom), seminars, team work

0 hours

16.

Other forms of activities

16.1.

Project tasks

45 hours

16.2.

Independent tasks

45 hours

16.3.

Homework

30 hours

17.

Grading method

17.1.

Tests

15 points

17.2.

Seminar work / project (presentation: written and oral)

45 points

17.3.

Activities and learning

15 points

17.4.

Final exam

0 points

18.

Grading criteria (points / grade)

up to 50 points

5 (five) (F)

from 51 to 60 points

6 (six) (E)

from 61 to 70 points

7 (seven) (D)

from 71 to 80 points

8 (eight) (C)

from 81 to 90 points

9 (nine) (B)

from 91 to 100 points

10 (ten) (A)

19.

Condition for signature and taking final exam

реализирани активности 15

20.

Language of instruction

македонски и англиски

21.

Quality assurance method

Механизам на интерна евалуација и анкети

22.

Literature

22.1.

Mandatory literature

22.2.

Additional literature